منابع مشابه
Nitric oxide in the nervous system.
Nitric oxide (NO) has only recently been appreciated as a normal biologic substance with a role in signal transduction. It was first identified as endothelial-derived relaxing factor in blood vessels and as the mediator of the tumoricidal and bactericidal actions of macrophages. NO's role as a neural messenger may be even more prominent. Biosynthesis of NO involves oxidation of the guanidine gr...
متن کاملNitric oxide in the peripheral nervous system.
Nitric oxide (NO) is a neurotransmitter and neuromodulator in the central nervous system, but this small labile substance also seems to serve as a peripheral neurotransmitter. Abundant evidence is now available that NO, synthesized from L-arginine by NO synthase (NOS), is a nonadrenergic noncholinergic relaxant transmitter of gastrointestinal smooth muscle. Electrically induced nonadrenergic no...
متن کاملContribution of Central Nervous System to Hypertension: role of Angiotensin II and Nitric Oxide
The contribution of the central nervous system (CNS) to the development and maintenance of high blood pressure is well established. Increased activity of the sympathetic nervous system during hypertensive conditions has been demonstrated experimentally and clinically. Different types of dysregulation in CNS, as seen by alterations in neurotransmitter production and baroreceptor reflex function,...
متن کاملMultidisciplinary approach to nitric oxide signaling: Focus on the gastrointestinal and the central nervous system.
Nitric oxide (NO), with close historical ties to cardiovascular physiology, is an important endogenous mediator, the most potent natural vasorelaxant known, involved in many biological functions . NO acts as an intra/intercellular signalling molecule and is a mediator in almost all organ systems . NO is known to occur in many cells types, including vascular endothelial cells, neurons, and epith...
متن کاملExtracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity.
Although reactive O2 species appear to participate in central nervous system (CNS) O2 toxicity, the exact roles of different reactive O2 species are undetermined. To study the contribution of extracellular superoxide anion (O2-) to CNS O2 toxicity we constructed transgenic mice overexpressing human extracellular superoxide dismutase (ECSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in ...
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ژورنال
عنوان ژورنال: Nihon Shuchu Chiryo Igakukai zasshi
سال: 1996
ISSN: 1340-7988,1882-966X
DOI: 10.3918/jsicm.3.69